Our laboratory focuses on understanding factors regarding innate immunity
of chronic infectious diseases, particularly induced by hepatitis B virus (HBV)
and mycobacteria, based on the protein interactions between MIF, CD44, and CD74.
Research themes of our laboratory are as follows.
To elucidate the role of MIF in protein interactions between CD44 and CD74.
To elucidate the role of protein interactions between MIF, CD44 and CD74 in innate immunity of chronic infectious diseases.
To develop the novel therapeutic or preventive vaccine and diagnostic method for HBV variants leading to vaccine escape, occult infection, or heaptocellular carcinoma (HCC).
To elucidate HCC mechanism induced by HBV or HCV variants related to the HCC.
To elucidate interferon resistant mechanism induced by the HBV or HCV variants related to the chronicity of liver disease.
To develop the molecular adjuvant based on diverse hsp65 sequences from uncultured human commensal bacteria or diverse Mycobacterium spp.